Best PDRN format for visible under-eye hollowness
- Abib PDRN Volume fill-it Booster crème is the most direct match to this concern in the three descriptions because it names both hollow areas and the under-eye area.
- Rejuran Turnover Ampoule is a face-focused ampoule for tone, texture, radiance and fine lines.
- Medicube PDRN Pink Peptide Serum is the clearest fit when brighter-looking tone matters alongside firmness and elasticity.
For a visible under-eye hollow or shadow, start with Abib PDRN Volume fill-it Booster crème. Abib specifies PDRN at 15,000 ppm and Volufiline at 10,000 ppm, and describes the combined formula as targeting hollow areas, under-eye appearance and elasticity. Choose Rejuran Turnover Ampoule for a broader tone-and-texture focus, or Medicube PDRN Pink Peptide Serum when uneven tone and a brighter look also matter.
What to compare first when firmness matters
Start with the appearance you want to change. A small shadowed hollow beneath the eye points toward a product whose maker explicitly names hollow-area plumping and the under-eye area. Fine lines across a wider area point toward a product that describes wrinkle or texture care. A dull or uneven-looking complexion puts tone and radiance closer to the top of the list.
Then read the product format and full positioning together. A targeted booster is designed to add a focused step to a routine, while a serum or ampoule is presented as a leave-on product with broader face-care goals. Those format names describe how the products are sold and used; the ingredient list and the maker’s stated concerns provide the more useful comparison for your goal.
A 2020 commentary on nonprescription topical skincare concludes that efficacy evidence is limited for most products it reviews. It describes three useful evaluation questions: whether the product penetrates the outer skin layer, whether its proposed action is plausible, and whether published, peer-reviewed, double-blind, placebo-controlled trials support the finished-product claim. Those questions help separate ingredient explanations from results measured on an actual formula.
There is human research on topical PDRN, but its scope is specific. A 2026 PLOS ONE report describes a randomized, double-blind, split-face comparison of 0.1% PDRN-850K eye cream and 0.1% retinol eye cream. The 31 enrolled participants were Chinese women aged 35 to 55 who had periocular fine lines or wrinkles and eye bags. After 28 days, the authors reported greater improvement in several periocular wrinkle measures and skin-structure measures on the PDRN-850K side than on the retinol side.
The authors describe 28 days as a short period for mature dermal remodeling and say early ultrasound changes may partly reflect hydration or plumping. A 2024 Dermatologic Surgery review listed in PubMed addresses polynucleotides in skin regeneration through the adenosine A2A receptor and salvage pathway. That mechanistic context helps explain why the ingredient is discussed in skin care; a review of mechanisms and a trial of one topical formula answer different questions from a head-to-head comparison of these three products.
A PubMed systematic review of PDRN and polynucleotides included seven randomized trials with 183 participants across skin rejuvenation and other skin concerns. Its authors cite small samples, varied protocols and different outcome measures as evidence limits. Rejuran’s c-PDRN® ingredient explanation describes PDRN’s use as an injectable in dermatology and its own c-PDRN® as a topical formula. Injection and leave-on products use different routes and finished formulas, so judge a topical choice by evidence on the topical formula itself.
PPM means parts per million; use a disclosed value as concentration information for its named ingredient, alongside the full formula and stated target area. Treat each concentration as a description of that formula.
Abib: the targeted hollow-area booster
Abib’s PDRN Volume fill-it Booster crème is the most directly aligned option for someone whose main concern is the look of under-eye hollowness. Its product description names hollow areas and under-eye areas, along with forehead lines, smile lines and neck wrinkles. It describes a targeted booster crème formulated with PDRN, Volufiline, retinal and peptides.
The disclosed concentrations are 15,000 ppm PDRN and 10,000 ppm Volufiline. Abib associates PDRN and Volufiline with visible plumping of hollow areas and the look of elasticity. Its retinal-and-peptide positioning adds skin texture, wrinkles and firmer-looking skin to the formula’s cosmetic focus.
The product is listed as a 30 mL tube. Its targeted format makes it a practical first comparison for shoppers who want to focus on one visible area, such as an under-eye hollow, rather than choose a product chiefly for overall radiance. The listed under-eye area is the skin around the eye; follow the package directions for placement and keep the cream out of the eyes.
Rejuran: an ampoule for tone, texture and radiance
Rejuran presents Turnover Ampoule as a c-PDRN® and hyaluronic acid product for tone, texture, radiance, lines and wrinkles. Its product page offers 30 mL and 50 mL sizes. The maker describes c-PDRN® as a marine-based ingredient and says the formula pairs it with hydrating hyaluronic acid.
Rejuran’s separate c-PDRN® ingredient explanation identifies c-PDRN® as a patented, hydrolyzed salmon-sperm DNA form of PDRN. Rejuran says Turnover Ampoule contains the “highest level of c-PDRN® available.”
This ampoule suits a shopper who wants a broader face-care product with a tone-and-texture emphasis and some wrinkle-focused claims. It is a less direct match for a distinct under-eye hollow because the product’s stated focus centers on overall tone, texture and radiance rather than a named hollow-area target. Its serum-like ampoule format is useful when a leave-on step with a broader face-care purpose feels more relevant than a targeted booster.
Medicube: a serum for mixed tone and firmness goals
Medicube’s PDRN Pink Peptide Serum is the clearest choice of these three when brightness and firmness have similar weight. The maker positions it for uneven skin tone and elasticity, with a brighter, more radiant complexion as a central goal. It presents the product as a lightweight serum for dull-looking, dry-looking or tired-looking skin.
Medicube’s ingredient listing for the serum identifies Rose PDRN as Rosa Damascena Extract plus Sodium DNA. It also lists a five-type peptide complex, niacinamide and adenosine. The product page associates the peptides with firmer-looking skin and fine lines, niacinamide with brighter-looking tone, and adenosine with the appearance of fine lines. Those combined ingredients explain the product’s dual emphasis on tone and firmness.
The serum can suit someone who wants to address a generally dull or uneven look while also caring about elasticity and fine lines. Its maker’s description does not foreground under-eye hollowness as a target, so a shopper focused on a specific hollow shadow has a more direct product-positioning match in Abib’s booster. Medicube’s pink appearance comes from vitamin B12, according to the product page, and the maker says the color does not stain skin.
Which of the three fits your priority?
| Product | Format and disclosed formula | Maker’s stated appearance focus | Best fit by stated priority |
|---|---|---|---|
| Abib PDRN Volume fill-it Booster crème | Targeted booster crème; 15,000 ppm PDRN and 10,000 ppm Volufiline, plus retinal and peptides | Hollow-area plumping, under-eye appearance, wrinkles, firmness and elasticity | A visible under-eye hollow or another localized hollow-area concern |
| Rejuran Turnover Ampoule | Ampoule; c-PDRN® and hyaluronic acid; 50 mL | Tone, texture, radiance, lines and wrinkles | A broader face-care step for texture, radiance and fine-line appearance |
| Medicube PDRN Pink Peptide Serum | Serum; Rose PDRN, five-type peptide complex, niacinamide and adenosine | Uneven tone, radiance, elasticity and fine-line appearance | Mixed brightness and firmness priorities |
This comparison uses each maker’s disclosed ingredients, format and appearance claims, alongside published research on topical PDRN.
FAQ
Which of these three is the best fit for under-eye hollowness?
Abib PDRN Volume fill-it Booster crème is the most direct match by product positioning. Its description specifically names hollow areas and under-eye areas, and it discloses PDRN and Volufiline concentrations. That makes it the clearest selection when the concern is a visible hollow or shadow, while Medicube and Rejuran describe broader tone, texture or radiance aims.
Does a higher PDRN ppm figure mean firmer-looking results?
No. No. PPM describes the stated concentration of an ingredient; match that figure with the product’s other ingredients and named appearance focus when choosing for visible firmness. Compare a product’s target area, additional ingredients and product-specific evidence with its concentration disclosure.
Which product makes more sense when brightening matters too?
Medicube PDRN Pink Peptide Serum is the clearest match for a combined tone-and-firmness goal. Its stated focus includes uneven tone and radiance, and its ingredient listing pairs Rose PDRN with peptides, niacinamide and adenosine. Rejuran Turnover Ampoule is another option when tone, texture and radiance are the broader priorities.
Can a topical PDRN cream change a hollow under-eye contour?
A topical cream is an appearance-care step applied to the skin, so judge it by visible surface appearance such as plumpness, smoothness and fine lines. For a structural contour change, discuss procedure options with a qualified clinician.